中科院:寨卡病毒感染会导致小头畸形

    发布时间:2016-05-12   来源:中华康网   
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近日,记者从中科院获悉:中科院遗传与发育生物学研究所许执恒团队与军事医学科学院微生物流行病研究所秦成峰团队合作,首次建立寨卡病毒小头畸形动物模型,并证实寨卡病毒可以直接导致小头畸形的发生。国际一流医学杂志《细胞·干细胞》今日将刊登此报道。

研究团队在哺乳动物小鼠中发现寨卡病毒可以于胚胎脑内快速复制,并感染神经干细胞,造成神经干细胞的增殖与分化异常,以及神经元的大量死亡,最终导致大脑皮层变薄和小头畸形。此次研究也为进一步探索寨卡病毒致病机制和相关治疗打下良好基础。

据了解,2015年以来,寨卡病毒感染在南美洲爆发并在全球范围内播散蔓延。2015年3月至2016年3月间,寨卡病毒在巴西爆发的同时,巴西确诊了6000多名新生婴儿患有小头畸形,比往年高出20倍,而这些婴儿的母亲大多感染了寨卡病毒。


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