牵牛子的药理作用

    发布时间:2015-11-30   来源:中华康网   
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泻下。

牵牛子甙的化学性质与泻下素 (jalapin)相似。有强烈的泻下作用。牵牛子甙在肠内遇胆汁及肠液分解出牵牛子素、刺激肠道,增进蠕动,导致泻下。据动物试验,黑丑,白丑泻下作用并无区别。

利尿。

利尿原理与增强肾脏活动有关,使尿量增加,大量服用对肾脏有刺激性,使肾脏充血,发生血尿。

对神经系统的影响。

大量服用可引起神经系统损害,尤以舌下神经易受损害,故舌之运动麻痹而致语言障碍,重者可致昏迷。

杀虫。

体外试验对蛔虫和绦虫有一定杀灭效果。

【传统应用】

水肿、腹水证。

牵牛子苦寒,其性降泄,既能泻下,又能利尿,

使水湿从二便排除,适用于水肿、腹水等证。其逐水力虽比甘遂、大戟等缓和,但究属峻下逐水之品,以水湿停滞,正气未衰者为宜??傻ビ?,或入复方。单用如《千金要方》治水肿,单用牵牛子末服以小便利为度。复方常与木香、厚朴等行气药配伍,以提高疗效。如《普济本事方》治四肢肿满,配以厚朴;《郑氏小儿方》治小儿水肿,配青皮或木香;《儒门事亲》禹功散,治停饮肿满配以小茴香,或加木香。

痰饮咳喘证。

本品能泻肺气,逐痰饮,用治肺气壅滞,痰饮咳喘,面目浮肿者,如《保婴集》?;贫崦?,治小儿肺胀喘满,胸高气急…痰涎潮塞,用黑丑、白丑与大黄、槟榔为末服。

食积便秘证。

本品有泻下、通便、去积作用。用治肠胃湿热积滞,便秘腹胀。如《本草衍义》治大肠风秘壅热结涩,以牵牛子配桃仁为丸服。

虫积腹痛证。

本品能去积杀虫,并可借其泻下作用排出虫体。治蛔虫、绦虫及虫积腹痛者可与槟榔、使君子同用,研末送服,以增强去积杀虫之功。

牵牛子的性味归经

【性味】 苦辛,寒,有毒。

①《别录》:"苦,寒,有毒。"

②《药性沦》:"味甘,有小毒。"

③《日华子本草》:"味苦莶。"

【归经】 入肺,肾,大、小肠经。

①《纲目》:"走气分,通三焦,达右肾命门。"

②《雷公炮制药性解》:"入大、小肠二经。"

③《本草通玄》:"入肺,大、小肠。"

④《本草新编》:"入脾与大、小肠,兼通膀胱。"

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